T cell receptor tyrosine phosphorylation. Variable coupling for different activating ligands.
نویسندگان
چکیده
منابع مشابه
Protein tyrosine phosphorylation in T cell signaling.
This review discusses in considerable detail the tyrosine phosphorylation events that couple the T cell antigen receptor to downstream signaling pathways. First, the protein kinases that catalyze these tyrosine phosphorylation are introduced, then the phosphatases that mediate removal of phosphate from tyrosine residues. Next, we discuss the molecular clock work by which these enzymes initiated...
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Adaptive immune responses are driven by interactions between T cell antigen receptors (TCRs) and complexes of peptide antigens (p) bound to Major Histocompatibility Complex proteins (MHC) on the surface of antigen presenting cells. Many experiments support the hypothesis that T cell response is quantitatively and qualitatively dependent on the so-called strength of TCR/pMHC association. Most av...
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In a study published inCell, Xu et al. (2008) raised the intriguing possibility that tyrosine residues present in the immunoreceptor tyrosine-based activation motifs (ITAMs) of the cytoplasmic domain of the CD33 subunit of the T cell receptor (TCR) are sequestered in the membrane. Here, they are inaccessible to tyrosine kinases that would otherwise drive signaling. As a consequence, the authors...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1987
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)45256-8